Plasma Levels of HDL Cholesterol and sCAMs in 20 Low-HDL Subjects -  Download Table

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Some state that the prevalence of statin trials has actually been tainted by 'market sponsorship', affected by 'analytical deception', and riddled with 'flawed approach',,. Those who challenge the cholesterol hypothesis are implicated of 'cherry-picking' the data. Paradoxically, pro-statin researchers themselves are the ones who are guilty of cherry-picking. A recent article in The Lancet, released in 2016, supposed to end the statin debate, ostensibly to silence dissenting views.

For circumstances, there are 44 randomised regulated trials (RCTs) of drug or dietary interventions to lower LDL-C in the primary and secondary prevention literature, which reveal no benefit on death. Many of these trials did not decrease CVD occasions and a number of reported substantial damage. Yet, these studies have not received much promotion.

The result dumbfounded many specialists, stimulating restored scepticism about the accuracy of the cholesterol hypothesis. There also appears to be no clear reduction in coronary heart illness mortality in western European countries from statins for main and secondary prevention. More recently, a post-hoc analysis revealed no benefit of statins (pravastatin) in elderly people with moderate hyperlipidaemia and hypertension in primary avoidance, and a non-significant instructions towards increased all-cause mortality amongst adults 75 years and older.

Similarly, the recent report of the efficacy of the newest 'hit' drug evolocumab (Repatha, a PCSK-9 inhibitor) was underwhelming, despite the media buzz. Published in The New England Journal of Medicine, the paper reported that evolocumab (together with a statin) reduced LDL-C by a whopping 60%, yet equated into only a 1.

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In addition, evolocumab did not decrease total or cardiovascular death. Rather, there was  CHOLESTEROL SCAMS -significant boost in mortality from CVD (n=251) compared to placebo (n=240), and a non-statistically considerable boost in general death in the speculative group (n=444) compared to placebo (n=426). In other words, none of the patients who took the drug lived longer than those taking placebo.

As noted in an article in The Daily Telegraph (UK) in May 2017, European individuals in the trial had no advantage in avoiding any tough results. When looking at the totality of the proof, the sobering outcomes of these studies have left many medical professionals wondering whether the regulation to lower LDL-C strongly utilizing pharmacotherapy has actually been misguided.